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Human anecdotal reports and off-label use in regenerative clinics support its gut-repairing potential particularly when traditional treatments fall short

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Epitalon mechanism is better understood at the enzymatic level (AANAT upregulation, pCREB activation) but the full picture of how it achieves tissue-specific pineal protection remains unclear

The study protocol with further details on the study design, procedures, and outcome assessment was published previously, as well as the initial 12 month outcomes of the LOLA arm [7, 14]

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